Yellowstone to Yukon Conservation Initiative or Y2Y is a transboundary Canada–United States not-for-profit organization that aims to connect and protect the 2,000 miles (3,200 kilometres) Yellowstone-to-Yukon region. Its mission proposes to maintain and restore habitat integrity and connectivity along the spine of North America's Rocky Mountains stretching from the Greater Yellowstone ecosystem to Canada's Yukon Territory. It is the only organization dedicated to securing the long-term ecological health of the region.

Since 1993, more than 450 partner groups have joined forces to support the shared mission and vision. Y2Y's work is a collaborative effort of conservation groups, government agencies, Indigenous governments, landowners, wildlife scientists, planners, businesses, economists, and other individuals and groups interested in protecting native wildlife, ecological processes, and wilderness in the Rocky Mountains of North America. Existing national, state, and provincial parks and wilderness areas anchor the system, while the creation of new protected and special management areas provide the additional cores and corridors needed to complete it. This network is built upon the principles of conservation biology, various focal species assessments, the knowledge of local and traditional residents, and the requirements for sustainable economies.

American Prairie is a prairie-based nature reserve in Central Montana, United States, on a mixed grass prairie ecosystem with migration corridors and native wildlife. This wildlife conservation area is being developed as a private project of the American Prairie Foundation (APF). This independent non-profit organization aims to include over 3 million acres (12,000 km²) through a combination of both private and public lands.

American Prairie provides public access to its land for all types of outdoor recreation including hiking, mountain biking, hunting, and fishing. The predominant economic activity in the region is the raising of cattle on homestead parcels along with adjacent rangeland leased from the federal government. Ranchers in the region are invited to adhere to wildlife-friendly standards on their ranches and required when grazing their cattle on American Prairie's parcels. Within large but securely fenced areas, American Prairie is developing a bison herd with attention to heritage genetics and minimal cattle introgression. Wildlife-friendly fencing allows the natural movement of wildlife such as pronghorn. Animals like prairie dogs are welcome amidst the native vegetation.

The Rewilding Institute is an organization concerned with the integration of traditional wildlife and wildlands conservation to advance landscape-scale conservation. It was founded by environmental activist Dave Foreman.

The Rewilding Institute's mission is to work toward the survival and flourishing of large carnivores in North America by promoting the establishment of suitable habitats in the wilderness, which are permanently interconnected as to allow their natural movement. They believe that humans and large carnivores can and should co-exist in North America. They wish to undo the damage done by over-hunting, over-logging, and exploitation of natural resources. Through continent-scale conservation efforts, they hope to prevent further extinctions of large predators, and to restore them to their function of maintaining the ecological balance of animal life in the wild. They have proposed reestablishing wild populations of wolves in interconnected, protected habitats, so that they can resume their ecological role. As part of their program, they have worked to get wildlife crossings included in interstate highway projects.

The Blue Frontier Campaign is a United States marine conservation activist organization founded by David Helvarg in 2003.

The Campaign has established a nationwide network of grassroots (the marine conservation community or Blue Movement calls this 'seaweed') lobbyists. It is campaigning for an American Oceans Act to protect what the members call "our public seas" and is working to improve ocean policies in the 23 coastal states of the United States. Blue Frontier supports maritime community activists by distributing model policies and practices. Its other objectives include the creation of books, a TV documentary series, and other educational materials on ocean exploration and stewardship. The first such creation was the 2005 - 2006 Ocean and Coastal Conservation Guide. The Blue Vision Conference in Washington DC in July 2004 and Blue Vision Mid-Atlantic Conference at the National Aquarium in Baltimore in April 2005 were the start of a series of seminars to introduce seaweed activists to oceanographers, port officials, and other marine stakeholders. Annual awards called "The Breakers" are presented in ten categories: Art & Entertainment, Conservation Science, Marine Education, Best Business Practices, and Hero of the Seas.

Future plans for the Campaign include endowing a fellowship for investigative reporting on waste, fraud and abuse on America's Seas, working to include marine education in middle school and high school curricula, and developing a media campaign that highlights lessons from the past American frontier, and "applies these to our new blue one".

The directors of the Campaign represent other activist organizations including Clean Ocean Action, The Democracy Collaborative, EarthEcho International, Khaled Bin Sultan Living Oceans Foundation, National Alliance for Hispanic Health, Reef Relief, and Save Our Shores. It also has a panel of over twenty advisors.

The Seaweed Rebellion is an informal marine environmentalist activist movement in the United States. Deriving its name from an analogy with grassroots democracy, the movement comprises disparate organizations with the common aim of protecting the oceans, seas and coasts of the United States.

The Blue Frontier Campaign is an umbrella organization aiming to coordinate these groups into a common voice to achieve effective lobbying of federal and state policy makers.

The name was first applied to a 1947 court case between the United States and California over who owned the sea bed, and the associated oil deposits, off the state coast but is now heard rarely in that context.