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Diabetes mellitus cured - George's experience
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== Efficacy of Long Wheat (LW) in Diabetes Control == [[File:LW.EfficacyInDiabControl.jpg|thumb|Click to enlarge picture]] Scientific evidence corroborating [[User:Georgedappilly|Georgedappilly]]'s claim (2009) on hypoglycemic efficacy of[[Diabetes mellitus cured - George's experience#Name in different languages|Long Wheat]] had been lying dormant for one and a half decades in a [http://diabetes.org.in/journal/2001_july-sept/original_article5.pdf Scientific Paper] [2]. Unfortunately the conclusion of the paper was in the negative on hypoglycemic effect of LW. This turned out to be a '''blessing in disguise''' for [[User:Georgedappilly|Georgedappilly]]. '''A staunch opponent of Long Wheat Mash Diet Regimen [[Diabetes mellitus cured - George's experience#Long Wheat Mash Diet Regimen.28LWMDR.29|LWMDR]] dug out the 14 year old study paper. I followed the link & at the very first glance itself noticed the positive fact contained in the included data [http://diabetes.org.in/journal/2001_july-sept/original_article5.pdf (TAble II of the paper)] [2]. This is a '''panacea''' for Diabetics but a '''dust in the eye''' for some others! [[File:LW.EfficacyInDiab.jpg|Centre|thumb|Click to enlarge picture]] The point that authors left unnoticed in the paper & caught my attention as '''very important''' is: '''the increase in blood sugar that happened due to the experimental diet in ''two'' fortnights was reverted by the next ''one'' fortnight in the case of Group I (who used Dicoccum whole Wheat flour) but not so in the case of Group II (who used Bread Wheat flour)!!!''' This study also indicates that even LW flour in the form of '''''unleavened bread''''' works (not only mash!) in regulating the Blood Sugar of Diabetes patients. The referred ''paper'' is certainly a great encouragement to all those who are on [[Diabetes mellitus cured - George's experience#Long Wheat Mash Diet Regimen.28LWMDR.29|LWMDR]] as well as those who are contemplating on trying [[Diabetes mellitus cured - George's experience#Long Wheat Mash Diet Regimen.28LWMDR.29|LWMDR]]. '''Usual life-cycle of the dreaded disease named Diabetes as understood by [[User:Georgedappilly|me]]''' Most persons think & propagate that Diabetes is a syndrome and not a disease; hence incurable. I totally disagree with both. Diabetes is also considered to be caused by the impairment of Pancreas (to be more precise, of Beta-cells which produce the hormone Insulin). From the time of reading about Insulin resistance (IR) I beg to differ with the Pancreas-BetaCell theory also. === Insulin Resistance, one of the triggers and sustainers of Diabetes === Insulin is a hormone produced by the beta cells of gland Pancreas. Initially it is attached to C-peptide as "Siamese twins" and gets detached on maturing in blood. Half life period of endogenous Insulin is estimated to be 5 minutes (whereas that of C-peptide is 30 min). It is Insulin that helps Glucose molecules enter cells from Blood easily and normslise the Blood Glucose level. When the quantum of Glucose is more than what is needed to meet the immediate energy requirements, the excess quantity is stored as Glycogen in Liver and further as fat at other parts of the body. When the storage spaces overflow, cells find it difficult to receive Glucose at the prevailing rate and signal the Insulin receptors to reduce their sensitivity. This is known as '''Insulin resistance (IR)'''. IR in turn reduces Glucose (G) absorption/removal from Blood (B). In my opinion this phenomenon is Diabetes. This leads to increased BG levels and a host of subsequent problems generally known as Diabetic complications. Misinterpreting the increased levels of BG (alias Blood Sugar - BS) being caused by shortage of Insulin, body intelligence signals Pancreas to enhance production. This may give a temporary relief but leads to higher levels of Insulin & Glucose in Blood as the IR still prevails. Increased BS levels lead to further increase in IR! Aaaaand the vicious circle continue obviously till...... Misunderstanding the increased levels of BG/BS being caused by shortage of Insulin, patients are advised and resorts to: A. physical exercises, B. oral therapies to whip Pancreas for producing more Insulin, C. inject extraneous Insulin, etcetera in order to force cells to absorb more Glucose from Blood. Being unaware of IR and due to taste and enjoyment considerations, patients continue to take sweet/starch in improper quantities. This in turn cause further hardships to cells. This leads to further increase of IR to face the enhanced challenge. This further worsens the situation and pushes the BS level to still higher values! Subsequently we enhance the therapy level. This vicious circle continues till the "unstable phase" alias "Brittle Diabetes" emerge!! ''' Four cases compared to show role of IR in trigger & sustenance of DM ''' {| class="wikitable" ! Parameter ! Case1 Me Diab cured ! Case2 IFG Relative ! Case3 Wife of an acquaintant ! Case4 Friend on Insulin inj ! Case5 Friend's sonSurApn on exercise only ! Case6 Boban Relative ! Remarks |- | Date | 03Aug2016 | 26Sep2016 | 11Nov2016 | ..Dec2014 | 30Jan2021 | FebMar2022 | |- | FBS* | 95 | <font color=#EE0000>''' 109'''</font> | <font color=#EE0000>''' 218'''</font> | <font color=#EE0000>''' 150'''</font> | 114 | 127 | * mg/dL |- | PPBS mg/dL | 86 | 79 | <font color=#EE0000>''' 190.7** '''</font> | <font color=#EE0000>''' 200* '''</font> | 116 | 170(ND/Calc) | * Average **eAG (A1C) |- | HbA1c % | 5.0 | ND | <font color=#EE0000>''' 8.1 '''</font> | <font color=#EE0000>''' 9+ '''</font> | 6.30 | 6.7 | ND=Not Done |- | FSI micro U/mL | 5.41 | <font color=#990000>''' 11.2 '''</font> | <font color=#990000>''' 15.6 '''</font> | <font color=#EE0000>''' 200+ '''</font> | 40.12 | 6.83 | Range 2.6 - 24.9 |- | TriG mg/dL | 54 ! 156 | 91.4 | 143 | 169 | 131 | <150 |- | HDL mg/dL | 59 | 63 | 75 | 49 | 32 | 42 | > 40 |- | IR(1) | <font color=#550000>''' 1.269 '''</font> | <font color=#770000>''' 3.014 '''</font> | <font color=#CC0000>''' 8.39 '''</font> | <font color=#EE0000>''' 74 '''</font> | 11.29 | | FSI×FBS÷405 <=1.0 |- | IR(2) | 0.915 | <font color=#AA0000> '''2.476''' </font> | <font color=#550000> 1.218 </font> | <font color=#EE0000>''' 2.918 '''</font> | 5.28 | | TriG÷HDL range <=2.0 |- | Insulin Inj | Nil | Nil | ? | 30-0-30 | Nil | Nil | |- | Tab1 | Nil | Nil | ? | Glucobay (50) 1-1-1 | Nil | Nil | |- | Tab2 | Nil | Nil | ? | Galvus met (50/1000)☆ 1-0-1 | Nil | Nil | ☆>Vildagliptin 50 + Metformin 1000 |- | Tab3 | Nil | Nil | ? | Nil | Nil | Nil | |} === Analysis === My FBS is less than 100 with fasting Serum Insulin (FSI) '''only 5.41'''. My relative has FBS more than 100 '''even''' with FSI 11.2; '''more than double of mine'''. This is a conspicuous exhibition of IR & Insulin being more in Blood even at beginning of Diabetes! She is only at impaired fasting Glucose (IFG) stage, not full blown diabetic according to modern medicine standards! Wife of my acqaintant has FBS 218, more than both the cases mentioned above '''even''' with FSI 15.6; '''which is almost 300% of mine and 150% of the second case'''. This again exhibit the role of IR on Diabetes & even excess Insulin being unable to hold Blood Sugar at normal levels! She is on Diabetic medication as well! My friend had FSI 200+ with three Insulin shots daily; third dose decided based on Supper PPBS! In spite of all the "exercises" he has FBS around 150!! Fasting Blood Sugar (FBS) of case1 is the least of the four, in spite of the fasting serum Insulin (FSI) being the lowest!!! Comments are welcome. === Effect of Diabetes on subsystems &/or components of human body === '''PRIMARY: (usually go unnoticed)''' # Blood sugar level exceeding upper limits (FBS >100 mg/dl, PPBS>140 mg/dl) # HbA1C increasing (normal range: 4.2% - 5.7%) # Cells being deprived of Oxygen & Glucose; getting filled with Carbon dioxide. (Glucose deprivation by Insulin Resistance and others by Glycosylated Haemoglobin alias HbA1c) '''SECONDARY: (obvious & leads to detection)''' # Frequent urination, persisting &/or unclenched thirst & repeating hunger. # Quick & unexplainable weight loss. # Persistent tire & fatigue unresolved even by food intakes and rest. # Possible misunderstanding among young couples sometimes leading to family breakdown due to '''diabetic sexual dysfunction''' '''TERTIARY: (affecting quality of life & confidence)''' # Numbness in lower parts of legs (ankles & feet). [[File:Degenerating leg of a prolonged diabetic.JPG|thumb|CLICK TO ENLARGE PICTURE <font color=#EE0000>Leg of a prolonged Diabetes patient</font>]] # Even minor skin injuries developing to prolonged wounds. # Loss of sensation. (Even ant-bites on wounds being not sensed.) # Liver enlargement & associated/subsequent problems '''FIERCE FINALE: Diabetic neuropathy sometimes culminating in:-''' # Diabetic neuropathy gangrene of legs – leading to amputations. # Diabetic retinopathy – irreversible loss of sight. # Diabetic nephropathy – irreparable kidney damage. # Diabetic brain hemorrhage (Stroke)– lifelong total or partial paralysis. # Atherosclerotic Heart Disease (Silent Angina) – the FINAL event. === The beaten track of Diabetes management === <font color="green">'''Stage 1:'''</font> Starts with exercise & diet control (quantity restriction & Glycemic Index based food swapping). <font color="blue">'''Stage 2:'''</font> Progress to low dose medication usually ½ Tab once daily in addition to stage 1 practices. <font color="blue">'''Stage 3:'''</font> Advance to higher doses of Tabs + Stage 1 practices. <font color="blue">'''Stage 4:'''</font> Switch to stronger Tabs in Stage 3 practices. <font color="orange">'''Stage 5:'''</font> Progress further to INSULIN injection (initially once daily, then twice, thrice & finally with every meal) in addition to Stage 1 practices. <font color="orange">'''Stage 6:'''</font> Then combination of a few of the above. <font color="red">'''Stage 7:'''</font> Combination (union) of all the above (diet control, exercise, tabs & insulin injections). <font color="red">'''Stage 8:'''</font> '''Penultimate, the UNSTABLE phase''' where prescribed dose of medicines pulls to hypoglycemia & reduced dose shoots the blood sugar up! (this topples the peace of mind as well as courage). This phase is known as Brittle Diabetes among medical professionals. '''Stage 9:''' '''Finally the BREAKDOWN phase''' when the patient gives up all restrictions on diet and lifestyle in utter despair, realising the futility of decades long struggling and compromises. ** There are two more stages which cannot be uniquely placed in the above sequence. These are relatively recent developments. <font color="brown">'''Bariatric surgery.'''</font> This surgical procedure reduces the food intake capacity and gives satiety with lesser quantity. That in turn reduces Blood Sugar lelevel as well as body mass. <font color="cyan">'''Insulin Pump Implantation.'''</font> As indicated by the name a pump that sends Insulin to bloodstream is implanted on the patient. It works on battery power and has a refillable/replaceable storage of Insulin. Pumping rate is presetable. The approximate size is comparable to a matchbox. === Some Diabetic Neuropathy Gangrene cases === Anxious waiting! Wondering what surprise this time? Fingers or foot!? <gallery mode=slideshow> Image:DiabeticNeuropathyGangreneCaseOneA.jpg| A patient on a Railway station corridor (<font color=#EE0000>Click ''right button'' to enlarge in '''new window'''</font>) Image:DiabeticNeuropathyGangreneCaseTwoAndThree.jpg|Awaiting the turn to know which finger(s) will go this time! ? (<font color=#EE0000>Click to enlarge pic (''right button'' to enlarge in '''new window'''</font>)) Image:DiabeticNeuropathyGangereneCaseFour.jpg|Anxiously awaiting the turn '''before surgery''' (<font color=#EE0000>Click to enlarge pic (''right button'' to enlarge in '''new window'''</font>)) Image:DiabeticNeuropathyGangereneCaseFourAfterProcedure.jpg|'''Ready to return home after surgery''' (<font color=#EE0000>Click to enlarge pic (''right button'' to enlarge in '''new window'''</font>)) Image:DiabeticNeuropathyGangereneCaseFive.jpg|Anxiously awaiting the turn (<font color=#EE0000>Click to enlarge pic (''right button'' to enlarge in '''new window'''</font>)) Image:DiabeticNeuropathyGangereneCaseSix.jpg|A lady anxiously awaiting the turn (<font color=#EE0000>Click to enlarge pic (''right button'' to enlarge in '''new window'''</font>)) Image:DiabeticNeuropathyGangereneCaseSeven.jpg|Anxiously awaiting the turn (<font color=#EE0000>Click to enlarge pic (''right button'' to enlarge in '''new window'''</font>)) Image:DiabeticNeuropathyGangereneCaseEight.jpg|Returning after procedure (<font color=#EE0000>Click to enlarge pic (''right button'' to enlarge in '''new window'''</font>)) Image:DiabeticNeuropathyGangereneCaseNine.jpg|Anxiously awaiting the turn; both the legs are already bandaged & already in protective footcare.(<font color=#EE0000>Click to enlarge pic (''right button'' to enlarge in '''new window'''</font>)) Image:DiabeticNeuropathyGangreneCaseTen.jpg|On public road side with one or two fingers already removed (<font color=#EE0000>Click to enlarge pic (''right button'' to enlarge in '''new window'''</font>)) Image:DiabeticNeuropathyGangreneCaseEleven.jpg|Fifth finger too of right foot was removed on some previous visit!! (<font color=#EE0000>Click to enlarge pic (''right button'' to enlarge in '''new window'''</font>)) Image:DiabeticNeuropathyGangreneCaseTwelve.jpg|Left person with all five fingers removed; right one with both legs in Diabetic shoes (<font color=#EE0000>Click to enlarge pic (''right button'' to enlarge in '''new window'''</font>)) Image:DiabeticNeuropathyGangereneCaseProtectiveFootware.jpg|Diabetic Neuropathy Gangrene Case Protective Footware (black pair on right).(<font color=#EE0000>Click ''right button'' to enlarge in '''new window'''</font>) Image:DiabeticNeuropathyGangreneCaseThirteen.jpg|Medical dressing of both legs moist due to lose of skin by Diabetic Gangerene. '''Right click''' to enlarge picture in '''new window'''. </gallery>= '''A MalayalaM news paper report''' Met two Diabetic patients suffering severe pain due to gangrened foot, on a railway platform. This sight forced me to a news paper office near by. I explained the encounter & my different experience with LWMDR. The reporter is nice & was patient enough to listen to me for 2 hours! They published reports at their printed & online editions. [http://www.rashtradeepika.com/shugar/ A Malayalam news paper report]. '''A different experience - Diabetes cured''' The [https://en.wikipedia.org/wiki/Diabetes_Mellitus diabetes mellitus] of [[User:Georgedappilly]] is <u>'''''cured'''''</u>. Sample [https://traplarva.blogspot.com/2009/09/part-6.html lab results] are given there. Details (in vernacular language MalayalaM) [https://traplarva.blogspot.com/2009/09/blog-post_08.html are placed there]. The [https://diabetescured090909.blogspot.com/2009/10/my-diabetes-is-cured-do-you-want-to.html English version]of procedures, experiences & results is released. Type 2 diabetese is supposed and popularly accepted by experts world over to be [https://en.wikipedia.org/wiki/Diabetes_Mellitus#Cures_for_type_2_diabetes incurable]. That one is what is cured in him by diet management (appropriate technology). Comment: To monitor your condition, preferably have periodical test using a suitable test kit and/or consultation to doctors. '''My latest Blood test report'''[[File:Mylatestbloodtestreport.jpg|thumb|CLICK TO ENLARGE PICTURE]] This is done as part of routine quarterly cardiology check up. Completing a decade of diagnosing Diabetes. All the tested parameters are normal, in range. {| class="wikitable" ! Sl No. ! Parameter ! Test method ! Result/value ! Unit ! Ref. Range |- | 1 | FBS | Hexokinase | 95 | mg/dL | 70-100 |- | 2 | Cholesterol | CHOD PAP | 129 | mg/dL | <200 |- | 3 | Triglycerides | GPO Enzymatic | 54 | mg/dL | <150 |- | 4 | HDL Cholesterol | Homogenous enzymatic | 59 | mg/dL | >40 |- | 5 | LDL Colesterol | Homogeneous enzymatic | 62 | mg/dL | <100 |- | 6 | VLDL | Calculated | 10 | mg/dL | 10-30 |- | 7 | Cholesterol/HDL ratio | Calculated | 2 |- - | <4.5 |- | 8 | Blood Urea Nitrogen | GLDH Urease kinetic method | 9.3 | mg/dL | 8-23 |- | 9 | Creatinine | Jaffes Kinetic method | 1 | mg/dL | 0.60-1.30 |- | 10 | Total Leukocyte Count | TC | 6300 | cells/cumm | 4000-10000 |- | 11 | Platelet Count |- - | 156 | thousand/cu.mm | 150-400 |- | 12 | Haemoglobin% | Hb | 13.5 | g/dL | 13-16 |- | 13 | Packed Cell Volume | PCV | 42.9 | % | 40-54 |- | 14 | Glucose 2 Hr PPBS | Hexokinase method | 86 | mg/dL | <140 |- | 15 | Insulin fasting | ECLIA | 5.41 | micro U/ml | 2.60-24.90 |}
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