Editing User:Sean McFarland

{{User data}}

===Hello Everyone!===

{|style="border:2px solid #003c4f; margin-left:.1em; margin-top:2px; margin-bottom: 2px; -moz-border-radius:10px;" align="center" width="100%"
|[[Image:Sean_McFarland.jpg|150px|left|A picture of me, Sean McFarland!]]
|As you may have already gathered, my name is Sean McFarland, and I am currently a junior pursuing a B.S. in molecular biology (with minors in nanotechnology, chemistry, honors, and possibly creative writing) at Clarion University of Pennsylvania. Over the course of this (Spring '08) semester, I will be seeking to detail a device or idea involving nanotechnology that will help further the goals of Appropedia in improving the human condition. As my major and future career inclinations would dictate, I am primarily interested in a project that would include material of a biological persuasion. After I do some reading and reviews of the literature currently out there, I'll be sure to continue to update this page as I flesh out exactly what I'd like to do.
|} 

===Areas of Interest===
* Somatic gene therapy
* Transgenic food crops
* Computer / web programming

===Current Project Ideas===
* Solar-powered UV lamp for water sterilization.
* Use of silicon nanowires in batteries to improve energy density.
* Use of nanodevices in DNA delivery, improving upon methods in somatic gene therapy and crop engineering.

===Project Decision===
After much thought, I have decided to go with the third project idea/area, "Use of nanodevices in DNA delivery, improving upon methods in somatic gene therapy and crop engineering," however, the focus may change depending upon the content further research turns up. Regardless, it is assured that it will be something to do with the field of nanomedicine. Below, find a list of sources that I am beginning to compile.

The other morning (1/23/08) I read an [http://www.sciencedaily.com/releases/2008/01/080118101931.htm article] detailing the potential for using highly charged water ions propelled via electrospray to facilitate the entry of genes into a variety of cell types. The key term here was ''cheap'' (given that I am working off of an undergraduate budget), so I will look into this further and see if anything can be made of it. Quite exciting, considering it may provide me with a topic to cover this Appropedia project, a new avenue for undergraduate research, and material for my senior project!

Now that I have begun to consume the literature involving [[electrospray]] technology, I am cautiously optimistic that it could prove to be a very applicable and versatile technology to implement cheaply in a variety of settings. As such, I will be moving much of my future research in this area to the Electrospray project page, where I will continue to document what I find.

===Search Log===

Note: Resources followed by "***" are full-text. Those lacking this availability may be candidates for interlibrary loan. Those requested by interlibrary loan are marked LOAN(Date Requested).


* '''Google Scholar''': 
     [http://www.google.com/scholar?q=nanomedicine&hl=en&lr=&start=20&sa=N "nanomedicine" to page 3 of results, 3rd entry.]
# [http://isis.ku.dk/kurser/blob.aspx?feltid=72361 Nanomedicine: current status and future prospects] 2005 ***
# [http://www.nanomedicine.com/ Nanomedicine Book Site] 1996-2003 ***
# [http://www.pubmedcentral.nih.gov/picrender.fcgi?artid=544309&blobtype=pdf Optical tracking of organically modified silica nanoparticles as DNA carriers: A nonviral, nanomedicine approach for gene delivery] 2005 ***
# [http://ieeexplore.ieee.org/xpl/freeabs_all.jsp?arnumber=1204819 Assembly automation with evolutionary nanorobots and sensor-based control applied to nanomedicine] 2003
# [http://web.archive.org/web/20080404063050/http://www.sciencedirect.com:80/science?_ob=ArticleURL&_udi=B6T2K-45KNDFH-1&_user=1528729&_rdoc=1&_fmt=&_orig=search&_sort=d&view=c&_acct=C000053281&_version=1&_urlVersion=0&_userid=1528729&md5=c971c93a793df4a70a0d3920c8dbafb3 From molecular biology to nanotechnology and nanomedicine] 2002
# [http://www.springerlink.com/content/pqm2563334602u82/ Molecular Imaging Applications in Nanomedicine] 2004
# [http://books.google.com/books?hl=en&lr=&id=6Hi25r0dgjIC&oi=fnd&pg=PA45&ots=fw9fzpIEsP&sig=gtN1eQIhKijiefba8kyLG3e3oUE The Future of Nanofabrication and Molecular Scale Devices in Nanomedicine] 2002
# [http://www.neurosurgery-online.com/pt/re/neurosurg/abstract.00006123-200606000-00001.htm;jsessionid=HSnP1VhK0zCfy7yyp8JsJGHxj5fmpqSRZsMG0c0VDRQQq1hw7F2t!607026366!181195629!8091!-1 Toward the Emergence of Nanoneurosurgery: Part III-Nanomedicine: Targeted Nanotherapy, Nanosurgery, and Progress Toward the Realization of Nanoneurosurgery] 2006
# [http://web.archive.org/web/20100705072533/http://lipari.usc.edu/cs5xx/Cavalcanti02.pdf Autonomous Multi-Robot Sensor-Based Cooperation for Nanomedicine] 2006 *** 
# [http://www.nano2life.com/download/nanomed_landscape_zweck_nbt.pdf The emerging nanomedicine landscape] 2006 ***
# [http://www.ncbi.nlm.nih.gov/sites/entrez?db=pubmed&uid=16434033&cmd=showdetailview&indexed=google Nanomedicine for respiratory diseases] 2006 ***
# [http://www.ncbi.nlm.nih.gov/sites/entrez?db=pubmed&uid=17292064&cmd=showdetailview&indexed=google Nanotechnology, nanomedicine, and the development of new, effective therapies for cancer] 2005
# [http://www.ncbi.nlm.nih.gov/sites/entrez?db=pubmed&uid=17070960&cmd=showdetailview&indexed=google Nanomedicine: developing smarter therapeutic and diagnostic modalities] 2006
# [http://www.futuremedicine.com/doi/full/10.2217/17435889.2.4.401?cookieSet=1 Nanomedicine: how it could reshape clinical practice] 2007 ***
# [http://www.ncbi.nlm.nih.gov/pubmed/17081650?ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVAbstractPlus Particulate nanomedicines] 2006

     [http://www.google.com/scholar?q=nano+gene+therapy&hl=en&lr=&start=0&sa=N "nano gene therapy" to page 3 of results, 7th entry.]
# [http://www.nature.com/gt/journal/v9/n6/pdf/3301665a.pdf Polyion complex micelles as vectors in gene therapy – pharmacokinetics and in vivo gene transfer] 2002 ***
# [http://www.ncbi.nlm.nih.gov/sites/entrez?db=pubmed&uid=14729076&cmd=showdetailview&indexed=google Chitosan-DNA nanoparticles as non-viral vectors in gene therapy: strategies to improve transfection efficacy] 2004 
# [http://www.ualberta.ca/~csps/JPPS7(2)/K.Turan/chitosan.htm In vitro characterization and delivery of chitosan-DNA microparticles into mammalian cells] 2004 ***
# [http://www.ncbi.nlm.nih.gov/sites/entrez?db=pubmed&uid=15262422&cmd=showdetailview&indexed=google Development of a non-viral multifunctional envelope-type nano device by a novel lipid film hydration method] 2004
# [http://pubs.acs.org/cgi-bin/article.cgi/nalefd/2006/6/i04/pdf/nl0500555.pdf Covalently Linked Au Nanoparticles to a Viral Vector: Potential for Combined Photothermal and Gene Cancer Therapy] 2006 ***
# [http://www.ncbi.nlm.nih.gov/sites/entrez?db=pubmed&uid=16202449&cmd=showdetailview&indexed=google Characterization of folate-chitosan-DNA nanoparticles for gene therapy] 2006 
# [http://www.ncbi.nlm.nih.gov/sites/entrez?db=pubmed&uid=15815682&cmd=showdetailview&indexed=google Gene therapy progress and prospects: targeted gene repair] 2005
# [http://www.ncbi.nlm.nih.gov/sites/entrez?db=pubmed&uid=16462855&cmd=showdetailview&indexed=google Gene therapy progress and prospects: magnetic nanoparticle-based gene delivery] 2006
# [http://www.ncbi.nlm.nih.gov/sites/entrez?db=pubmed&uid=12628320&cmd=showdetailview&indexed=google Biodegradable nanoparticles for drug and gene delivery to cells and tissue] 2003
# [http://www.ncbi.nlm.nih.gov/sites/entrez?db=pubmed&uid=16457655&cmd=showdetailview&indexed=google Bio-functional inorganic materials: an attractive branch of gene-based nano-medicine delivery for 21st century] 2005
# [http://www.ncbi.nlm.nih.gov/sites/entrez?db=pubmed&uid=16475946&cmd=showdetailview&indexed=google Synthetic and natural polycations for gene therapy: state of the art and new perspectives] 2006
# [http://www.ncbi.nlm.nih.gov/sites/entrez?db=pubmed&uid=15816024&cmd=showdetailview&indexed=google A bio-recognition device developed onto nano-crystals of carbonate apatite for cell-targeted gene delivery] 2005
# [http://www.ncbi.nlm.nih.gov/sites/entrez?db=pubmed&uid=15816024&cmd=showdetailview&indexed=google A bio-recognition device developed onto nano-crystals of carbonate apatite for cell-targeted gene delivery] 2005


* '''Pubmed''':
     [http://www.ncbi.nlm.nih.gov/sites/entrez "nanomedicine" (Limited to free full-text) all 23 results.]
# [http://www.ncbi.nlm.nih.gov/pubmed/18178663?ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum Simulations of Electrophoretic RNA Transport Through Transmembrane Carbon Nanotubes] 2008 ***
# [http://www.ncbi.nlm.nih.gov/pubmed/17666347?ordinalpos=2&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum Integrated therapy and research progress in molecular therapy for intracranial tumor] 2007 ***
# [http://www.ncbi.nlm.nih.gov/pubmed/17643544?ordinalpos=3&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum Nanofabricated particles for engineered drug therapies: a preliminary biodistribution study of PRINT nanoparticles] 2007 ***
# [http://www.ncbi.nlm.nih.gov/pubmed/17614355?ordinalpos=4&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum Targeted pharmaceutical nanocarriers for cancer therapy and imaging] 2007 ***
# [http://www.ncbi.nlm.nih.gov/pubmed/17525514?ordinalpos=5&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum Future direction of nanomedicine in gastrointestinal cancer] 2007 ***
# [http://www.ncbi.nlm.nih.gov/pubmed/17489016?ordinalpos=6&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum Nanomedicine: techniques, potentials, and ethical implications] 2006 ***
# [http://www.ncbi.nlm.nih.gov/pubmed/17404004?ordinalpos=7&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum Targeted drug-carrying bacteriophages as antibacterial nanomedicines] 2007 ***
# [http://www.ncbi.nlm.nih.gov/pubmed/17263428?ordinalpos=8&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum FePt@CoS(2) yolk-shell nanocrystals as a potent agent to kill HeLa cells] 2007 ***
# [http://www.ncbi.nlm.nih.gov/pubmed/17022621?ordinalpos=10&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum Nanotools for megaproblems: probing protein misfolding diseases using nanomedicine modus operandi] 2006 ***
# [http://www.ncbi.nlm.nih.gov/pubmed/16902417?ordinalpos=11&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum Surface coatings determine cytotoxicity and irritation potential of quantum dot nanoparticles in epidermal keratinocytes] 2007 ***
# [http://www.ncbi.nlm.nih.gov/pubmed/16861836?ordinalpos=12&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum Nanoparticles in diagnostics and therapy: towards nanomedicine] 2006 ***
# [http://www.ncbi.nlm.nih.gov/pubmed/16549776?ordinalpos=14&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum Nano neuro knitting: peptide nanofiber scaffold for brain repair and axon regeneration with functional return of vision] 2006 ***
# [http://www.ncbi.nlm.nih.gov/pubmed/16467913?ordinalpos=15&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum Nanomedicine and protein misfolding diseases] 2005 ***
# [http://www.ncbi.nlm.nih.gov/pubmed/16407415?ordinalpos=16&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum Cytotoxicity of water-soluble fullerene in vascular endothelial cells] 2006 ***
# [http://www.ncbi.nlm.nih.gov/pubmed/16391365?ordinalpos=17&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum Is nanotechnology ready for primetime?] 2006 ***
# [http://www.ncbi.nlm.nih.gov/pubmed/16051701?ordinalpos=19&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum Organically modified silica nanoparticles: a nonviral vector for in vivo gene delivery and expression in the brain] 2005 ***


*'''Altavista''':
     [http://www.altavista.com/web/results?itag=ody&kgs=1&kls=0&q=Electrospray+ionization-principles+and+practice&stq=20 "Electrospray ionization-principles and practice"]
# [http://www.wiley.com/legacy/wileychi/ms/articles/677_a.pdf Electrospray : Principles and Practice] 1997 ***
# [http://web.missouri.edu/~glaserr/8160f06/ESI-review.pdf Internal Energy and Fragmentation of Ions Produced in Electrospray Sources] 2003 ***
# [http://www.sisweb.com/referenc/applnote/app-74.htm A Examination of Source Design in Electrospray-TOF Using SIMION 3D] 1999 ***


*'''AllTheWeb''':
     [http://www.alltheweb.com/search?cat=web&cs=iso88591&rys=0&itag=crv&_sb_lang=pref&q=fabricating+electrospray&o=20 "fabricating electrospray" to page 10]
# [http://web.archive.org/web/20110626145731/http://www.nd.edu:80/~changlab/pump-spray.pdf An integrated micropump and electrospray emitter system based on porous silica monoliths] 2006 ***
# [http://www.bentham.org/cnano/sample/cnano1-1/D0004N.pdf Tools of Nanotechnology: Electrospray] 2005 ***
# [http://www.lbl.gov/tt/publications/2211pub.pdf Microfabricated Monolithic Multinozzle Emitters for Nanoelectrospray Mass Spectrometry] 2007 ***
# [http://pubs.acs.org/cgi-bin/article.cgi/ancham/1999/71/i19/pdf/ac990252m.pdf A Design for Low-Flow Sheathless Electrospray Emitters] 1999 ***
# [http://www.ornl.gov/sci/csd/pdfs/OBMS_VanBerkel_ESEC%20bibliography.pdf Electrochemistry Inherent in Electrospray Ion Sources] N/A *** A list of papers.


*'''Wikipedia''':
     [http://en.wikipedia.org/wiki/Electrospray Electrospray]
# [http://www3.interscience.wiley.com/cgi-bin/abstract/109930844/ABSTRACT Electrospray ionization-principles and practice] 2005 LOAN(1/30/08)
# [http://www.ncbi.nlm.nih.gov/pubmed/10934434 A brief overview of the present status of the mechanisms involved in electrospray mass spectrometry] 2000
# [http://pubs.acs.org/cgi-bin/article.cgi/ancham/1996/68/i01/pdf/ac9509519.pdf Analytical properties of the nanoelectrospray ion source] 1996 ***
# [http://www.ncbi.nlm.nih.gov/pubmed/9588029?ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVAbstractPlus InJection adaptable fine ionization source ('JaFIS') for continuous flow nano-electrospray] 1998 LOAN(1/30/08)
# [http://pubs.acs.org/cgi-bin/article.cgi/ancham/2006/78/i04/pdf/ac051480l.pdf Fabrication of Internally Tapered Capillaries for Capillary Electrochromatography Electrospray Ionization Mass Spectrometry] 2006 ***
# [http://web.archive.org/web/20080404063056/http://www.sciencedirect.com:80/science?_ob=ArticleURL&_udi=B6V0W-4MYMFNB-12&_user=1528729&_rdoc=1&_fmt=&_orig=search&_sort=d&view=c&_acct=C000053281&_version=1&_urlVersion=0&_userid=1528729&md5=cc03b3e4b9d9dd47f8149b178d182760 High-aspect-ratio silica nozzle fabrication for nano-emitter electrospray applications] 2007 LOAN(1/30/08)
# [http://www3.interscience.wiley.com/cgi-bin/abstract/102526878/ABSTRACT A simple method for fabrication of silver-coated sheathless electrospray emitters] 2003
# Book: [http://worldcat.org/oclc/35637508&referer=one_hit Electrospray ionization mass spectrometry : fundamentals, instrumentation, and applications by Richard B Cole] 1997 LOAN(1/30/08) --- Scratch that, attempted to request book, but resulted in an error. Will try again later.
# Book: [http://worldcat.org/oclc/48691417&referer=one_hit Applied electrospray mass spectrometry by Birendra N Pramanik;  A K Ganguly;  Michael L Gross] 2002 
# Book: [http://worldcat.org/oclc/33818563&referer=one_hit Biochemical and biotechnological applications of electrospray ionization mass spectrometry by A Peter Snyder;  American Chemical Society. Division of Analytical Chemistry.;  American Chemical Society. Meeting] 1995

     [http://en.wikipedia.org/wiki/Colloid_thruster Colloid thruster]

     [http://en.wikipedia.org/wiki/Taylor_cone Taylor cone]

     [http://en.wikipedia.org/wiki/Desorption_electrospray_ionization Desorption electrospray ionization]


*'''Random Sources''':

# [http://www.eng.monash.edu.au/mnrl/papers/j/Yeo_etal_Biomaterials_26_6122_2005.pdf AC electrospray biomaterials synthesis] 2005 ***
# [http://www.nd.edu/~changlab/documents/PRLACspray.pdf A New AC Electrospray Mechanism by Maxwell-Wagner Polarization and Capillary Resonance] 2004 ***
# [http://pubs.acs.org/cgi-bin/article.cgi/ancham/1999/71/i15/pdf/ac981412h.pdf Electrospray Deposition as a Method for Mass Fabrication of Mono- and Multicomponent Microarrays of Biological and Biologically Active Substances] 1999 ***
# [http://www.rsc.org/delivery/_ArticleLinking/DisplayArticleForFree.cfm?doi=b316836k&JournalCode=CP Electrochemical and theoretical aspects of electrospray ionisation] 2004 ***
# [http://www.ncbi.nlm.nih.gov/pubmed/17578733?ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum Submerged electrosprays: a versatile approach for microencapsulation] 2007 LOAN(1/30/08)

If you happen to stumble upon this page and would like some food for thought, I'd suggest looking up the [http://web.archive.org/web/20090201045837/http://mfoundation.org:80/sens MFoundation], whose SENS plan stands to benefit all human beings the world over.


--[[User:Sean McFarland|Sean McFarland]] 16:03, 30 January 2008 (PST)
[[Category:PH254]]