Editing Malaria

[[File:Trois kits de test de dépistage rapide positif pour le paludisme(malaria) sur table 03.jpg|thumb]]

Malaria is an [[infectious disease]] of humans and other animals caused by microorganism of the genus Plasmodium. The microorganisms first infect the liver, and then act as parasites within red blood cells, causing symptoms that typically include fever and headache, in severe cases progressing to coma or death. A map showing the occurence of the disease on earth can be found [http://global.ihi.com/travel+insurance/travel+advice/travel+guide/malaria.aspx here]

== Types of malaria ==

[[File:Anopheles-range-map.png|thumb|Map indicating the prevailance of the different types of mosquito-species that spread malaria. Using insect-repelling plants specifically tailored to that mosquito-species could prove more effective]]

Five species of malaria can be distinguished, triggered by different Plasmodium species. Severe disease is caused by P. falciparum while the disease caused by P. vivax, P. ovale, and P. malariae is generally a milder form that is rarely fatal. P. knowlesi, prevalent in Southeast Asia, causes malaria in macaques and can also cause severe infections in humans. Most of the types of malaria occur on generally the same places on earth, for an example, see [http://web.archive.org/web/20150423152844/http://www.map.ox.ac.uk:80/browse-resources/endemicity/Pf_mean/world/ the occurence of P.falciparum] and [http://www.scidev.net/en/news/map-reveals-global-threat-from-the-other-malaria-.html P. ovale]

Depending on the type of malaria, the treatment (and thus the drugs provided will vary).<ref>[http://web.archive.org/web/20141120063331/http://www.malariasite.com:80/malaria/Treatment3.htm Treatment of malaria varies depending on type]</ref><ref>[http://cid.oxfordjournals.org/content/44/8/1075.full P. falciparum malaria and P. vivax malaria may require different treatments]</ref>

== Preventing malaria ==

To some extend, some people (often those living in area's where the disease is endemic) have evolved to be partially genetically resistant to malaria. This resistance is often accomplished by diseases as sickle cell disease, thalassaemias, glucose-6-phosphate dehydrogenase deficiency as well as the presence of Duffy antigens on the subject's red blood cells.

People that do have not acquired such defenses will soon still be able to attain natural resistance trough a malaria vaccine. Some vaccines are already on the market but are not yet 100% efficient.

Suitable additional measures to prevent malaria the [[Mosquito control|destruction of malaria larvae in the vicinity]] (ie by removing freshwater in the vicinity, or by killing the larvae (either manually or by using predatory organisms). Other measures are the use of

* clothing. It is advisable to use clothing that covers the entire body, atleast in the late afternoon and night and /or when travelling to waterlogged areas or any other areas where anopheles mosquitoes are present in large numbers) Note that the mosquitoes will often be more eager to sting during late afternoon/night
* mosquito nets
* [[Disease-repelling plants|insect-repellents]] (ie sprayed on the person's skin, or aerated in rooms)
* preventive herbal medicine, ie goldenseal (Hydrastis canadensis), Chinese goldenthread (Coptis chinensis), and milk thistle (Silybum marianum)<ref>[http://www.altmd.com/Articles/Malaria--Encyclopedia-of-Alternative-Medicine Preventive herbal medicine]</ref>

Malaria medication is often only usable for a short duration (ie upto a few months) and depending on the medication, may also be expensive to very expensive, rendering them useless to (often economically challenged) people living within regions where the disease is endemic. They are however very useful to aid workers and provide 100% efficiency (depending on the medication used).

== Treating malaria ==

{{References needed}}

Malaria is a deadly disease and treatment should be discussed with qualified medical professionals. See also [[wikipedia:Malaria#Treatment]]. The following includes a discussion of both proven and less-common treatments:

Drugs such as quinine (the oldest anti-malaria drug), artesunate, artemisinin, primaquine may be used. These drugs may be more or less effective depending on where you acquired the disease. This as there are varying degrees of resistance against one or several of the treatments, see [http://web.archive.org/web/20150710144411/http://www.cmaj.ca:80/content/164/5/654/F1.full this map] Quinine is no longer effective but can be extracted from the bark of the cinchona tree. Artemesinin can be extracted from Artemisia annua. Generally specific cultivars of the crop are used such as [http://www.york.ac.uk/news-and-events/news/2006/gates-grant/ Mediplant's Artemis], [http://web.archive.org/web/20160723232142/http://pageant.org.uk/artemisia01.htm Anamed A-3] Some other plants too can be used to treat malaria. These include wormwood (Artemesia annua),Dichroa febrifuga (aka shang shan),<ref>[http://web.archive.org/web/20171109103841/http://sstmyanmar.com:80/tourism/Interest/Myanmar_herbs.html Dichroa febrifuga is used in herbal medicine centers in Myanmar]</ref> and extracts from Microglossa pyrifolia. The latter shows promise in treating drug-resistent strains of P. falciparum.

Note that to increase efficiency, it is best to combine artemesinin with another drug. These drugs are called ACT's (Artemisinin-based combination therapies) and are now even recommended by the WHO as first-line treatment for Plasmodium falciparum malaria in most countries where resistance has compromised the efficacy of older drugs. Two frequently used ACT's are artesunate-amodiaquine and dihydroartemisinin-piperaquine

Anamed distributes starter kits for growing artemisia annua (Anamed A-3), see http://www.anamed.net/English_Home/anamed_artemisia_programme/artemisia_starter_kit/artemisia_starter_kit.html

== Notes ==

<references />

== External links ==

* [[Wikipedia:Malaria]]: also contains map showing regions where drug resistance (against several drugs) occurs
* http://en.wikipedia.org/wiki/Antimalarial_medication
* SMS fighting malaria, see [http://www.wired.com/epicenter/2010/04/sms-fights-malaria-scourge-in-africa/ here]
* [http://vaccinenewsdaily.com/vaccine_development/318424-drug-candidate-prevents-growth-of-malaria-parasite/ Some advances in genetic modification of organisms to fight malaria]
* [http://www2.merriam-webster.com/cgi-bin/mwmednlm?book=Medical&va=malaria NIH/Merriam Webster Medical Dictionary]
* [http://www.statista.com/statistics/267178/percentage-of-top-funders-for-malaria-research-and-development Statista.com]:Top founders of malaria research 2007 to 2011

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[[Category:Malaria|Malaria]]
[[Category:Diseases]]
[[Category:Water]]