The accurate and timely detection of tuberculosis (TB) is critical in limiting the spread of the disease. As such, new methods are under development that are fast, accurate, inexpensive, and portable, meeting the needs of resource-limited environments where the disease is most prevalent.

Detailed description of the solution

The device utilizes luciferase reporter mycobacteriophages (LRM), which are assays that emit light when they interact with live TB bacteria in a sample of saliva/sputum. The project is centered on developing a versatile luminescence detection tool to capture and interpret the emitted light. The test can provide results within a day, compared to at least one week for most traditional methods. Finally, a disposable-type testing cartridge is being developed, allowing for rapid and easier preparation of samples for testing.

Designed by

• Designed by: The project is a collaborative effort between InterScience, UAlbany, the Albert Einstein College of Medicine of Yeshiva University, and SUNY Downstate Medical Center.
• Manufacturer (if different): InterScience develops the imaging system, intelligent computer algorithm, and overall integration of the TB detection system while UAlbany is developing the disposable cartridges.
• Manufacturer location: n/a

When and where it was tested/implemented

Clinical testing of a prototype was planned at the State University of New York Downstate Medical Center.

Funding Source

InterScience received $750,000 grant from the National Institutes of Health (NIH) (2001).

References