{"id":40212,"key":"Global_Health_Medical_Device_Compendium/SMART_II_Cholera_O1","title":"Global Health Medical Device Compendium/SMART II Cholera O1","latest":{"id":1267566,"timestamp":"2026-09-10T13:50:05Z"},"content_model":"wikitext","license":{"url":"https://www.appropedia.org/Appropedia:Copyrights","title":"CC-BY-SA-4.0"},"source":"[[File:Smartcholera.jpg|thumb]]\n\n{{GHMDC device data\n| health-topic = Waterborne diseases\n| classification = Diagnosis\n| scope = Commercialized\n| type = Rapid test\n| manufacturer-location = Maryland, United States\n}}\n\nCholera continues to be a major cause of illness and death in developing countries, especially in post-natural disaster or post-conflict settings. In these settings, laboratory diagnosis of cholera may not be possible due to lack of electricity and trained personnel. Timely diagnosis is essential for appropriate treatment.\n\n== Detailed description of the solution ==\n\nThe SMART II Cholera O1 test is a rapid diagnostic test that detects Vibrio cholerae-specific antigens within a human fecal sample. It can be performed in about 15 minutes, can be used by an unskilled technician, requires no electricity, and stores at room temperature.\n\n== Relevance to developing country settings ==\n\nCholera is almost exclusively limited to developing country settings. These tests were use in field trials in Bangladesh, Mexico, and Madagascar.\n\n== Manufacturer ==\n\n* Manufacturer: New Horizons Diagnostics Corporation\n* Manufacturer location: Columbia, Maryland USA\n\n \n\n== Funding Source ==\n\nThis device has funding from private sources.\n\n== References ==\n\n=== Peer-reviewed publication ===\n\nJ A Hasan, A Huq, M L Tamplin, R J Siebeling and R R Colwell. (1994.) A novel kit for rapid detection of Vibrio cholerae O1. J. Clin. Microbiol., 32(1):249. Link available [http://jcm.asm.org/content/32/1/249.full.pdf+html here].\n\nKalluri P, Naheed A, Rahman S, Ansaruzzaman M, Faruque AS, Bird M, et al. (2006). Evaluation of three rapid diagnostic tests for cholera: does the skill level of the technician matter?. Trop Med Int Health, 11(1), 49-55. Link available [http://www.ncbi.nlm.nih.gov/pubmed/16398755 here].\n\nNato F, Boutonnier A, Rajerison M, Grosjean P, Dartevelle S, Guenole A et al. (2003.) One-step immunochromatographic dipstick tests for rapid detectrion of Vibrio cholerae O1 and O139 in stool samples. Clin Diagn Lab Immunol, 10(3), 476-478. Link available [http://www.ncbi.nlm.nih.gov/pmc/articles/PMC154973/ here].\n\n=== Internally generated reports ===\n\nNew Horizons Diagnostics Corporation. (2004). Cholera SMART II. PDF available [http://web.archive.org/web/20110313062642/http://www.nhdiag.com:80/pdf/Cholera_O1_Smart_II_insert.pdf here].\n\n{{Page data\n| sdg = SDG03 Good health and well-being\n| license = CC-BY-SA-3.0\n| language = en\n}}"}