{"id":39302,"key":"Global_Health_Medical_Device_Compendium/POCKET:_Miniaturized_Immunoassay_System","title":"Global Health Medical Device Compendium/POCKET: Miniaturized Immunoassay System","latest":{"id":1267910,"timestamp":"2026-09-10T14:58:02Z"},"content_model":"wikitext","license":{"url":"https://www.appropedia.org/Appropedia:Copyrights","title":"CC-BY-SA-4.0"},"source":"[[File:Pocket.png|thumb]]\n\n{{GHMDC device data\n| health-topic = HIV/AIDS\n| classification = Diagnosis\n| made = No\n| replicated = No\n| manufacturer-location = Massachusetts, United States\n}}\n\nEarly detection of HIV can help to effectively control the spread of the virus. Existing diagnostic systems, especially enzyme-linked immunosorbent assays (aka ELISA), are bulky, expensive, and require electricity, lengthy incubation periods, and multiple pipetting stages. The POCKET combines the immunoassay unit and the detector unit into a portable and cost-effective model.\n\n== Detailed description of the solution ==\n\nA blood sample is delivered to each channel of the device and is analyzed by an antibody-detecting strip. Protein fragments on the strip bind HIV antibodies. A series of rapid, yet precise chemical assays are performed on detected antibodies for identification and quantification.\n\n== Designed by ==\n\n* Designed by: The Whitesides Research Group at Harvard University. Their home page is found [http://gmwgroup.harvard.edu/index.php here].\n* Manufacturing: Cambridge, Massachusetts, USA\n\n== When and where it was tested/implemented ==\n\nThe prototype was developed in 2004 at Harvard, and as of 2004, Harvard University's Office for Technology and Trademark Licensing has been negotiating with a start-up firm to commercialize the POCKET.\n\n== References ==\n\n=== Peer-reviewed publication ===\n\nLinder, V., Sia, S.K., &d Whitesides, G.M. (2005). Reagent-loaded cartridges for valveless and automated fluid delivery in microfluidic devices. Anal Chem, 77(1), 64-71.\n\nSia, S.K., Linder, V., Parviz, B.A., Siegel, A., & Whitesides, G.M. (2004). An integrated approach to portable and low-cost immunoassay for resource-poor settings. Angew Chem Int Ed Engl, 43(4), 498-502. PDF can be found [http://web.archive.org/web/20111208172618/http://gmwgroup.harvard.edu/pubs/pdf/889.pdf here].\n\n{{Page data\n| sdg = SDG03 Good health and well-being, SDG09 Industry innovation and infrastructure\n| license = CC-BY-SA-3.0\n| language = en\n}}"}