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'''Reduced concentration oral rehydration solution''' (or '''reduced osmolarity oral rehydration solution''') is less concentrated than traditionally used in [[oral rehydration therapy]]. Some tests have found it to result in "reduced need for unscheduled intravenous infusions, lower stool volume, and less vomiting compared with standard WHO rehydration solution."<ref>
 
'''Reduced concentration oral rehydration solution''' (or '''reduced osmolarity oral rehydration solution''') is less concentrated than traditionally used in [[oral rehydration therapy]]. Some tests have found it to result in "reduced need for unscheduled intravenous infusions, lower stool volume, and less vomiting compared with standard WHO rehydration solution."<ref>
[http://bmj.bmjjournals.com/cgi/content/full/323/7304/81 Reduced osmolarity oral rehydration solution for treating dehydration due to diarrhoea in children: systematic review] -- Hahn et al. In contrast, <ref>[http://www.ncbi.nlm.nih.gov/pubmed/10440307 Efficacy and safety of oral rehydration solution with reduced osmolarity in adults with cholera: a randomised double-blind clinical trial] (CHOICE study group, [[ICDDRB]]) failed to find a difference in cholera patients.</ref>
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[http://bmj.bmjjournals.com/cgi/content/full/323/7304/81 Reduced osmolarity oral rehydration solution for treating dehydration due to diarrhoea in children: systematic review] -- Hahn et al</ref>. In contrast, <ref>[http://www.ncbi.nlm.nih.gov/pubmed/10440307 Efficacy and safety of oral rehydration solution with reduced osmolarity in adults with cholera: a randomised double-blind clinical trial] (CHOICE study group, [[ICDDRB]]) failed to find a difference in cholera patients.</ref>
    
However, concerns have been raised that this is unsuitable for universal use, as it may lead to a negative sodium balance in cholera patients, with very serious consequences.<ref> [http://jama.ama-assn.org/cgi/content/full/291/21/2632?etoc JAMA -- Clinical Concerns About Reduced-Osmolarity Oral Rehydration Solution]; [http://www.ncbi.nlm.nih.gov/pubmed/10440307 Efficacy and safety of oral rehydration solution with reduced osmolarity in adults with cholera: a randomised double-blind clinical trial]. CHOICE study group, [[ICDDRB]].</ref> For this reason [[starch-based oral rehydration solutions]] may be preferred methods of achieving the same effects with less risk, especially in serious cases.
 
However, concerns have been raised that this is unsuitable for universal use, as it may lead to a negative sodium balance in cholera patients, with very serious consequences.<ref> [http://jama.ama-assn.org/cgi/content/full/291/21/2632?etoc JAMA -- Clinical Concerns About Reduced-Osmolarity Oral Rehydration Solution]; [http://www.ncbi.nlm.nih.gov/pubmed/10440307 Efficacy and safety of oral rehydration solution with reduced osmolarity in adults with cholera: a randomised double-blind clinical trial]. CHOICE study group, [[ICDDRB]].</ref> For this reason [[starch-based oral rehydration solutions]] may be preferred methods of achieving the same effects with less risk, especially in serious cases.
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* [http://www.supply.unicef.dk/catalogue/bulletin9.htm New formulation of Oral Rehydration Salts (ORS) with reduced osmolarity] - Technical Bulletin from UNICEF, describing the user of a weaker solution, with the aim of reducing stool output.
 
* [http://www.supply.unicef.dk/catalogue/bulletin9.htm New formulation of Oral Rehydration Salts (ORS) with reduced osmolarity] - Technical Bulletin from UNICEF, describing the user of a weaker solution, with the aim of reducing stool output.
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[[Category:Oral rehydration therapy]]
 
[[Category:Medical care ]]
 
[[Category:Medical care ]]

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