Main page
New page
Upload file
Help
Community portal
Recent changes
Talk
Contributions
Create account
Enable dark mode
Enable read mode
Log in
View history
What links here
Related changes
Page information
Editing
Diabetes mellitus cured - George's experience
(section)
From Appropedia
Warning!
You are not logged in.
Log in
or
create an account
to have your edits attributed to your username rather than your IP, along with other benefits.
Anti-spam check. Do
not
fill this in!
=== Insulin Resistance, one of the triggers and sustainers of Diabetes === Insulin is a hormone produced by the beta cells of gland Pancreas. Initially it is attached to C-peptide as "Siamese twins" and gets detached on maturing in blood. Half life period of endogenous Insulin is estimated to be 5 minutes (whereas that of C-peptide is 30 min). It is Insulin that helps Glucose molecules enter cells from Blood easily and normslise the Blood Glucose level. When the quantum of Glucose is more than what is needed to meet the immediate energy requirements, the excess quantity is stored as Glycogen in Liver and further as fat at other parts of the body. When the storage spaces overflow, cells find it difficult to receive Glucose at the prevailing rate and signal the Insulin receptors to reduce their sensitivity. This is known as '''Insulin resistance (IR)'''. IR in turn reduces Glucose (G) absorption/removal from Blood (B). In my opinion this phenomenon is Diabetes. This leads to increased BG levels and a host of subsequent problems generally known as Diabetic complications. Misinterpreting the increased levels of BG (alias Blood Sugar - BS) being caused by shortage of Insulin, body intelligence signals Pancreas to enhance production. This may give a temporary relief but leads to higher levels of Insulin & Glucose in Blood as the IR still prevails. Increased BS levels lead to further increase in IR! Aaaaand the vicious circle continue obviously till...... Misunderstanding the increased levels of BG/BS being caused by shortage of Insulin, patients are advised and resorts to: A. physical exercises, B. oral therapies to whip Pancreas for producing more Insulin, C. inject extraneous Insulin, etcetera in order to force cells to absorb more Glucose from Blood. Being unaware of IR and due to taste and enjoyment considerations, patients continue to take sweet/starch in improper quantities. This in turn cause further hardships to cells. This leads to further increase of IR to face the enhanced challenge. This further worsens the situation and pushes the BS level to still higher values! Subsequently we enhance the therapy level. This vicious circle continues till the "unstable phase" alias "Brittle Diabetes" emerge!! ==== Four cases compared to show role of IR in trigger & sustenance of DM ==== {| class="wikitable" ! Parameter ! Case1 Me Diab cured ! Case2 IFG Relative ! Case3 Wife of an acquaintant ! Case4 Friend on Insulin inj ! Case5 Friend's sonSurApn on exercise only ! Case6 Boban Relative ! Remarks |- | Date | 03Aug2016 | 26Sep2016 | 11Nov2016 | ..Dec2014 | 30Jan2021 | FebMar2022 | |- | FBS* | 95 | <font color=#EE0000>''' 109'''</font> | <font color=#EE0000>''' 218'''</font> | <font color=#EE0000>''' 150'''</font> | 114 | 127 | * mg/dL |- | PPBS mg/dL | 86 | 79 | <font color=#EE0000>''' 190.7** '''</font> | <font color=#EE0000>''' 200* '''</font> | 116 | 170(ND/Calc) | * Average **eAG (A1C) |- | HbA1c % | 5.0 | ND | <font color=#EE0000>''' 8.1 '''</font> | <font color=#EE0000>''' 9+ '''</font> | 6.30 | 6.7 | ND=Not Done |- | FSI micro U/mL | 5.41 | <font color=#990000>''' 11.2 '''</font> | <font color=#990000>''' 15.6 '''</font> | <font color=#EE0000>''' 200+ '''</font> | 40.12 | 6.83 | Range 2.6 - 24.9 |- | TriG mg/dL | 54 ! 156 | 91.4 | 143 | 169 | 131 | <150 |- | HDL mg/dL | 59 | 63 | 75 | 49 | 32 | 42 | > 40 |- | IR(1) | <font color=#550000>''' 1.269 '''</font> | <font color=#770000>''' 3.014 '''</font> | <font color=#CC0000>''' 8.39 '''</font> | <font color=#EE0000>''' 74 '''</font> | 11.29 | | FSI×FBS÷405 <=1.0 |- | IR(2) | 0.915 | <font color=#AA0000> '''2.476''' </font> | <font color=#550000> 1.218 </font> | <font color=#EE0000>''' 2.918 '''</font> | 5.28 | | TriG÷HDL range <=2.0 |- | Insulin Inj | Nil | Nil | ? | 30-0-30 | Nil | Nil | |- | Tab1 | Nil | Nil | ? | Glucobay (50) 1-1-1 | Nil | Nil | |- | Tab2 | Nil | Nil | ? | Galvus met (50/1000)☆ 1-0-1 | Nil | Nil | ☆>Vildagliptin 50 + Metformin 1000 |- | Tab3 | Nil | Nil | ? | Nil | Nil | Nil | |}
Summary:
Warning!
All contributions to Appropedia are released under the CC-BY-SA-4.0 license unless otherwise noted (see
Appropedia:Copyrights
for details). If you do not want your writing to be edited mercilessly and redistributed at will, then do not submit it here! You are also promising us that you wrote this yourself, or copied it from a public domain or similar free resource.
Do not submit copyrighted material without permission!
Cancel
Editing help
(opens in new window)
This page is a member of 2 hidden categories:
Category:Pages too long
Category:Pages with sections nested too deep
Cookies help us deliver our services. By using our services, you agree to our use of cookies.
OK
Discussion